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Search results for "Denosumab"

Denosumab ( Prolia ) is a monoclonal antibody against receptor activator of nuclear factor-kappa B ligand ( RANKL ).The following safety issues associated with Denosumab exposure have been identified ...


Amgen has informed physicians of important safety information for Prolia ( Denosumab ) and updates to the Prescribing Information.Prolia was originally approved by the FDA ( Food and Drug Administrati ...


Key safety concerns with Denosumab ( Xgeva ) included in the Warnings and Precautions section of the existing product labeling involve the risks of osteonecrosis of the jaw ( ONJ ) and hypocalcemia. O ...


Denosumab ( Prolia ) is a human monoclonal antibody ( IgG2 ) that targets and binds with high affinity and specificity to RANKL, preventing activation of its receptor, RANK, on the surface of osteocla ...


Atypical femoral fractures have been reported rarely in patients with postmenopausal osteoporosis receiving long-term ( greater than or equal to 2.5 years ) treatment with Denosumab 60 mg ( Prolia ) i ...


The Food and Drug Administration ( FDA ) has expanded the use of Xgeva ( Denosumab ) to treat adults and some adolescents with giant cell tumor of the bone ( GCTB ), a rare and usually non-cancerous t ...