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Tumour necrosis factor alpha ( TNF-alpha ) is a cellular protein produced by the immune system and is an important mediator of many diseases, including inflammatory arthritis and inflammatory bowel di ...


Safety reviews of tumor necrosis factor-alpha ( TNF-a ) antagonists, Infliximab ( Remicade ), Etanercept ( Enbrel ), and Adalimumab ( Humira ) identified rare cases of serious skin reactions, includin ...


Amgen and Wyeth Pharmaceuticals have added a Boxed Warning to the Enbrel ( Etanercept ) US Prescribing Information to further strengthen and clarify information regarding the risk of infections, inclu ...


Tumor necrosis factor a ( TNF- alpha ) blockade has emerged as a useful therapy for collagen vascular diseases or graft-vs-host disease. Fungal infections complicating such therapy have been reported ...


Pfizer has announced top-line results from two pivotal Phase 3 trials from the Oral treatment Psoriasis Trials ( OPT ) Program, OPT Pivotal #1 ( A3921078 ) and OPT Pivotal #2 ( A3921079 ), evaluating ...


The European Commission ( EC ) has approved Cosentyx ( Secukinumab ) as a first-line systemic treatment of moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy. Cos ...