Drugs Xagena
Researchers at University of Aberdeen have made a finding that could pave the way for new drugs to treat osteoporosis and other bone diseases.
Their studies also suggest that cannabis use might affect users bone health, although researchers stress that further research would be required to confirm this.
As part of an Arthritis Research Campaign funded study into brittle bones and other diseases, the research team explored the effects of chemicals produced naturally in our body called endogenous cannabinoids on bone.
Cannabinoids act in the same way that cannabis does by attaching themselves to receptors in our body which then play a part in a number of the bodys processes including controlling our appetite.
The researchers reveal their discovery that these receptors are also present in bone cells and play a crucial role in regulating bone density and bone turnover.
They also discovered that if they used drugs to block the cannabinoid receptors, this was highly effective in preventing bone loss.
Stuart Ralston, who led the research project, and is now based at the University of Edinburgh, said: This is an important finding since it demonstrates that the receptors which cannabis acts upon are not only important in the nervous system, but also in the control of bone metabolism.
The fact that compounds which blocked cannabinoid receptors are highly effective at preventing bone loss is particularly exciting, since it shows that these drugs could provide us with a completely new approach to the treatment of osteoporosis and other bone diseases.
Ruth Ross, who is a cannabinoid research scientist at the University of Aberdeen, added: Cannabinoid receptor blockers have recently been shown to be safe and effective for the treatment of obesity. The fact that they may also be potent inhibitors of bone loss has major therapeutic implications. "
Conversely, the researchers also discovered that drugs which stimulate these receptors - and mimic the effects of cannabis were detrimental to bone and caused increased bone loss, which could, in turn lead to osteoporosis.
However, the most widely used of drug treatments for osteoporosis, cancer-related bone diseases, rheumatoid arthritis and other bone diseases are inconvenient to take and can be associated with various undesirable side effects.
Source: University of Aberdeen, 2005
XagenaMedicine_2005
