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Results of previous randomised trials have shown that interventions that lower LDL cholesterol concentrations can significantly reduce the incidence of coronary heart disease ( CHD ) and other major v ...


An animal study, published in the journal Cell Metabolism, found that the increased rate of cardiovascular complications in patients taking the cox-2 inhibitor Rofecoxib ( Vioxx ) may result from a ch ...


The FDA ( U.S. Food and Drug Administration ) has approved Tarceva ( Erlotinib ) in combination with Gemcitabine ( Gemzar ) chemotherapy for the treatment of advanced pancreatic cancer in patients who ...


Human growth hormone, or HGH, is a substance released by the pituitary gland that spurs growth and development in children and adolescents. As a drug, it can be prescribed legally only for three rare ...


Peroxisome proliferator–activated receptors ( PPARs ) are ligand-activated nuclear transcription factors that modulate expression of a large number of genes. In the United States, therapeutic agent ...


The enrollment in the Abciximab in Emergent Stroke Treatment Trial-II ( AbESTT-II ), the phase III trial of ReoPro ( Abciximab ) for the treatment of acute ischemic stroke, has been temporarily suspe ...


The FDA ( Food and Drug Administration ) has approved Lipitor ( Atorvastatin ) a cholesterol-lowering drug, to reduce the risk of stroke and heart attack in people with type 2 diabetes without evidenc ...


Novartis has a comprehensive portfolio of cardiovascular products both in the market ( Diovan and Lotrel ) as well as in development ( such as LAF237 and SPP100 ), for the treatment of hypertension, d ...


Eric J. Topol, chair of the Department of Cardiovascular Medicine at the Cleveland Clinic, asks, How can a drug that is associated with higher rates of both renal dysfunction and death than placebo — ...


The FDA ( Food and Drug Administration ) has asked Purdue Pharma, the makers of Palladone, to withdraw it from the market. FDA has acquired new information on serious and potentially fatal adverse ...


Black cohosh ( Cimicifuga racemosa ) is an herbal medicine used mainly to alleviate menopausal symptoms. Adverse reactions ( Ars ) to black cohosh include gastrointestinal irritation, headache, dizzi ...


Avandia ( Rosiglitazone ) is a member of the thiazolidinedione family of oral hypoglycemic agents used to improve glycemic control by increasing insulin sensitivity in muscle and adipose tissue and in ...


Stevens-Johnson syndrome ( SJS ) is a severe blistering rash affecting both skin and mucous membranes. The majority of cases have been attributed to drug exposures. The reaction begins with burning a ...


The Food and Drug Administration ( FDA ) issued a public health advisory to alert health care professionals, patients and their caregivers of reports of death and other serious side effects from overd ...


An Expert Panel, chaired by Eugene Braunwald, met on June 8th to review and assess important data associated with the acute heart failure treatment Natrecor ( Nesiritide ). The Panel, which was con ...


In a paper, published in the journal Cell, Christopher Glass, at the University of California, San Diego ( UCSD ) School of Medicine, and his colleagues showed that three nuclear receptor proteins – ...


According to Food and Drug Administration ( FDA ), all patients being treated with any type of antidepressant for any indication should be observed closely for clinical worsening, suicidality, and unu ...


FDA ( Food and Drug Administration ) has approved a program for Isotretinoin (Accutane and its generics), called iPLEDGE, aimed at preventing use of the drug during pregnancy. Women who are pregnant ...


European Commission approved Humira ( Adalimumab ) as a treatment for psoriatic arthritis and as first-line treatment of severe rheumatoid arthritis ( RA ) in Europe. The approval for psoriatic art ...


Mice lacking a key protein involved in cholesterol regulation have low-density lipoprotein ( LDL ) levels more than 50 percent lower than normal mice, and researchers suggest that inhibiting the same ...


A study by Howard Hughes Medical Institute investigators at Duke University Medical Center has provided evidence on how Nitroglycerin relieves chest pain. Nitroglycerin relaxes blood vessels to boo ...


Women who consume higher doses of non-aspirin painkillers are much more likely to develop high blood pressure than women who do not use them. " We sought to investigate whether higher doses of anal ...


Cox-2 selective inhibitors are used to relieve pain resulting from a variety of musculoskeletal disorders. Numerous studies have shown that their effectiveness in pain relief is similar to "tradition ...


The Food and Drug Administration ( FDA ) has approved new labeling for Cialis ( Tadalafil ), Viagra ( Sildenafil ), and Levitra ( Vardenafil ) regarding postmarketing reports of vision loss related t ...


Neurological complication may result from rapid withdrawal from Pregabalin ( Lyrica ). A report, published in the journal Annals of Neurology describes a serious adverse event experienced by a partic ...


A growing body of literature has supported a protective effect of Acetylsalicylic acid ( Aspirin ) and other nonsteroidal anti-inflammatory drugs ( NSAIDs ) on the development of cancer. Observationa ...


New results from the Women's Health Study, a long-term clinical trial of the effect of vitamin E and Aspirin on both the prevention of cardiovascular disease and of cancer, indicate that 600 IU of nat ...


According to Linus Pauling, two-time Nobel laureate and the world's foremost vitamin C proponent, the vitamin's versatility in illness prevention arises from its role in the manufacture of collagen, t ...


Children with a particular variation in the CYT19 gene metabolize arsenic differently than adults with the same genetic variant. The findings have important implications for the safety of drinking ...


Researchers at the University of Michigan have created the nanotechnology equivalent of a Trojan horse to smuggle a powerful chemotherapeutic drug inside tumor cells – increasing the drug’s cancer-kil ...


The FDA ( Food and Drug Administration ) has approved the selective COX-2 inhibitor Celebrex ( Celecoxib ) for the relief of the signs and symptoms associated with ankylosing spondylitis, a form of a ...


The FDA ( Food and Drug Administration ) approved Diovan ( Valsartan ), an ARB ( angiotensin receptor blocker ), for a new indication to reduce cardiovascular death in patients at high risk ( with lef ...


The FDA ( Food and Drug Administration ) has approved the New Drug Application ( NDA ) for Rozerem ( Ramelteon ) 8-mg tablets for the treatment of insomnia characterized by difficulty with sleep onse ...


An analysis of 19 randomized controlled trials involving COX-2 inhibitors ( selective cyclooxygenase-2 inhibitors ) suggests that these agents raise blood pressure more than either conventional nonste ...


Researchers from University of Pennsylvania School of Medicine have found additional evidence that may help explain how selective inhibitors of COX-2 might predispose individuals to heart disease and ...


Researchers at University of Aberdeen have made a finding that could pave the way for new drugs to treat osteoporosis and other bone diseases. Their studies also suggest that cannabis use might aff ...


Sodium Nitrite, a naturally occurring chemical and common meat preservative, is only used medically to treat cyanide poisoning. But if the results of a new animal study hold up under further research ...


The FDA ( Food and Drug Administration ) Antiviral Drugs Advisory Committee recommended the approval of the anti-HIV drug Tipranavir ( Aptivirus ), a protease inhibitor ( PI ). Tipranavir belongs to ...


The benefits of giving low dose Acetylsalicylic acid ( Aspirin ) to healthy individuals older than 70 to prevent cardiovascular disease are offset by increased risk of serious bleeding. Current US ...


Researchers at University of California San Francisco ( UCSF ) have compared younger versus older patients' desires / needs to escalate the dose of opioid pain medications they take -- a class of dru ...


Some commonly prescribed drugs may interfere with the electrical activity controlling the heartbeat, increasing the risk of sudden cardiac death. A study analyzed 775 cases of sudden cardiac death ...


After evaluation of the available data, and consideration of submissions from patients and health professionals, the Medicines Adverse Reactions Committee ( MARC ) has recommended that the COX-2 inhib ...


Health Canada is advising people who use Elidel ( Pimecrolimus ) cream and Protopic ( Tacrolimus ) ointment about safety information that indicates a potential cancer risk. Health Canada is recomme ...


Following discussions with the European Medicines Agency ( EMEA ), Pfizer has agreed to the suspension of use of anti-inflammatory drug, Bextra ( Valdecoxib ), in Europe as an interim measure pending ...


Researchers from the University of Minnesota in Minneapolis, reported seven patients who developed nonarteritic anterior ischemic optic neuropathy ( NAION ), after taking Viagra ( Sildenafil ) for ere ...


Public Citizen, a US consumer organization, petitioned the Food and Drug Administration ( FDA ) to immediately remove Pemoline ( Cylert ), an Abbott’s CNS stimulant used in the treatment of attention ...


Avonex ( Interferon beta-1a ) is approved for the treatment of patients with relapsing forms of multiple sclerosis to slow the accumulation of physical disability and decrease the frequency of clinica ...


Xigris has received FDA approval for increasing survival in high-risk adult patients with severe sepsis. Xigris ( Drotrecogin alfa, activated ) is a recombinant version of human Activated Protein ...


Bisphosphonates are drugs commonly used to prevent and treat osteoporosis in post-menopausal women. They are widely used in the management of advanced cancers that have metastasized to the bone, w ...


Linezolid ( Zyvoxam ), a synthetic antibacterial agent in a new class of antibiotics, the oxazolidinones, has been marketed in Canada since 2001. Linezolid is active against methicillin- and vancomyci ...